164 ANTIBACTERIAL EFFECT OF PULMONARY SURFACTANT
نویسندگان
چکیده
منابع مشابه
Effect of pulmonary surfactant protein
The effects of surfactant-associated protein A (SPA) on lipid adsorption to the air-water interface and accumulation of dipalmitoylphosphatidylcholine (DPPC) in the surface region were investigated at 37%. Dispersions used were bovine pulmonary lipid extract surfactant with or without neutral lipid (NL). Lipid adsorption was examined with the Wilhelmy plate technique and DPPC accumulation by mo...
متن کاملEffect of pulmonary surfactant combined
Abstract. – OBJECTIVE: To investigate and discuss the effect of early treatment with pulmonary surfactant (PS) on oxygenation functions in neonates with acute respiratory distress syndrome (ARDS), to understand the expression trend of serum transforming growth factor-beta 1 (TGF-β1) and bone morphogenetic protein 7 (BMP-7) in children with neonatal respiratory distress syndrome (NRDS), and to p...
متن کاملExogenous Pulmonary Surfactant as a Vehicle for Antimicrobials: Assessment of Surfactant-Antibacterial Interactions In Vitro
Owing to its unique surface-active properties, an exogenous pulmonary surfactant may become a promising drug delivery agent, in particular, acting as a vehicle for antibiotics in topical treatment of pneumonia. The purpose of this study was to assess a mutual influence of natural surfactant preparation and three antibiotics (amikacin, cefepime, and colistimethate sodium) in vitro and to identif...
متن کاملPulmonary surfactant
Pulmonary surfactant is a complex mixture of lipids and proteins that, by modulating surface tension during breathing, prevents alveolar collapse at exhalation and overdistention at inspiration. Surfactant is synthesized by type II pneumocytes, assembled in lamellar bodies and secreted at the air-liquid interface of the alveolus. This surface-active material is re-uptaken by alveolar type II ce...
متن کاملEffect of pulmonary surfactant on antimicrobial activity in vitro.
Time-kill curve experiments were performed with linezolid, doripenem, tigecycline, moxifloxacin, and daptomycin against Staphylococcus aureus and with colistin, moxifloxacin, and doripenem against Pseudomonas aeruginosa to evaluate the effect of porcine pulmonary surfactant on antimicrobial activity. Pulmonary surfactant significantly impaired the activities of moxifloxacin and colistin. When a...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1991
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199112000-00194